In a DSS-induced porcine colitis model, tryptophan supplementation ameliorated clinical symptoms and reduced gut permeability (Kim et al., 2010)
Reported adverse effects of IV glutathione include adverse cutaneous eruptions including potentially fatal Stevens-Johnson syndrome and toxic epidermal necrolysis, severe abdominal pain, thyroid dysfunction, renal dysfunction, and lethal complications such as air embolism or potentially fatal sepsis due to incorrect/unsterile method of IV administration, with side effects on the use of injectable glutathione for skin lightening including toxic effects on the liver, kidneys, and nervous system
In short, the gut microbiota influences brain function via the regulation of neurotransmitters and neurotrophic factors, maintenance of intestinal barrier and tight junction integrity, activation of enteric sensory afferents, production of bacterial metabolites, and modulation of mucosal immune responses [22]
10.1042/bj1470513 3 BensonA
Glutathione's antioxidant action does have a mild protective effect on melanocytes, the cells responsible for hair pigmentation, but it is not formulated or concentrated enough in typical supplement doses to make a meaningful difference to grey hair on its own
