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2 The GOAT/ghrelin/GHSR system 2.1 Synthesis and post-translational modification of ghrelin Ghrelin was initially discovered by Kojima et al

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5 Glucagon and metabolic surgery Today, metabolic surgery is one of the most effective weapons in the therapeutic arsenal against T2DM, and since its appearance, many surgical variants have been developed with varying degrees of success ( Figure 3 )