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Despite currently available therapeutics and advancements in the clinical management of heart failure and its associated complications, many challenges still remain as morbidity and mortality rates are showing no signs of decrease, (Tsao et al, 2022) highlighting unmet medical need to develop novel disease-modifying therapies for this disease
Dengler, R
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Yet this advantage disappears if the drug cannot reach adequate blood concentrations in the first place
Cho HY, Jedlicka AE, Chang FH, Marzec J, Bauer AK, Kleeberger SR
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