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Effects of NAD + precursor-based clinical interventions on the liver and isolated PBMCs Pioneering studies primarily conducted with healthy participants over short-term periods were designed to assess the dose tolerance and safety of NAD + precursors, particularly NR [76] (Table 2)

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Bottom line: The receptor desensitization story doesnt apply over the time periods that have been studied

Within experimental settings, BPC-157 is being investigated for its potential impact on the bodys natural repair capabilities