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The model was qualified in accordance with regulatory guidelines [31, 32]

The molecular and structural/functional changes translate to (1) Tubular atrophy, podocyte hypertrophy, glomerulosclerosis, and microvascular rarefaction and (2) glomerular basement membrane thickening, nephrosclerosis, and extracellular matrix accumulation, respectively [84]

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Whilst retatrutide is not currently available outside of clinical trials, understanding which patient groups may carry greater cardiac risk is important for both clinicians and patients considering future participation in trials or eventual clinical use