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Endonuclease G is an apoptotic DNase when released from mitochondria

Although the DSM-IV [44] does not explicitly define residual schizophrenia, it describes as typical a course of the illness in which positive symptoms diminish while negative symptoms persist

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Auspiciously, we found that PKM2 mediates DRD2-induced GSH production and is selectively expressed in astrocytes, indicating that PKM2 dimerization is an ideal approach to restore GSH synthesis and prevent side effects induced by effects on neuron functions