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Research has documented Ipamorelins GH release potency as comparable to GHRP-2 and substantially greater than GHRP-6 on a molar basis in rodent and primate GH secretion studies , establishing that the selectivity pharmacology of Ipamorelins pentapeptide structure does not compromise GH release potency relative to non-selective first-generation GH secretagogues

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They have upper volume limits that make them impractical for certain loading protocols

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