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In addition to sensitivity, it should be noted that the separation time in Figure 2 is about 5 min, which is much shorter than analysis time of HPLC (typically in ~30 minutes)

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Recent studies have reported that two drugs, MRTX1133 and BI-KRASG12D1-3, are able to selectively inhibit the viability of KRAS mutant tumour cells in clinical trials [123]

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