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In addition, abuse of opioids can occur in the absence of addiction

doi: 10.3389/fbioe.2025.1668524 Received 18 July 2025 Revised 04 November 2025 Accepted 13 November 2025 Published 05 January 2026 Volume 13 - 2025 Edited by George Alexander Truskey, Duke University, United States Reviewed by Wagner Moneda Telini, Centro Universitrio de Votuporanga, Brazil Mai Abusalah, al-Ahliyya Amman University, Amman, Jordan, Jordan Updates Copyright 2026 Xiao, Li, Mu, Sun, Wang, Chen, Ma, Cao, Yang, Shao, Ding, Cui and Du

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The influence of substituents on acidity is more pronounced in DMSO than in water, so Hammett parameters derived from aqueous p K a values actually underestimate substituent effects in reactions performed in non-hydrogen bonding media