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When researchers first set out to observe data from 141 previous studies, they expected to see a dramatic reduction in the risk of heart disease among one-a-day smokers as opposed to those who smoked a pack a day the equivalent of about 20 cigarettes

What follows is why that is, what the puff numbers really mean, and where the figures stop being reliable

The Content Expert Panel suggests investigators consider nicotine as derived from any source, including both natural and synthetic, when administering this protocol

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