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Who participates in First-in-Human trials, and how are participants informed and protected

J Biol Chem 279: 3987239879 [DOI] [PubMed] [Google Scholar] Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P (2005) Inaugural article: on the mechanism of sensing unfolded protein in the endoplasmic reticulum

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This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) (Morgan and Liu, 2011)