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Importantly, GLP-1RAs do not exert direct immunosuppressive effects but instead modulate inflammatory pathways indirectly through metabolic and cellular mechanisms, supporting a favourable safety profile when used alongside bDMARDs

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While ertugliflozin did not outperform placebo for MACE, it significantly reduced hospitalizations for HF by 30% ( The SCORED clinical study, which included 10,584 patients with T2DM and an estimated glomerular filtration rate (eGFR) of 2560 ml/m/1.73 m, evaluated the effects of sotagliflozin on cardiovascular death and hospitalization for HF

Drospirenone: pharmacology and pharmacokinetics of a unique progestogen