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The inhibition of protein kinase C (PKC), NADPH oxidase, and NF-B signaling exhibited anti-oxidative and anti-inflammatory effects in endothelial cells, accompanied by the upregulation of protective anti-oxidative enzymes [57]

(ii) CMS assigns values to the ACO for its performance on each measure as follows: (A) Values of four, two, or zero for each measure for which the ACO's performance places it in the top, middle, or bottom third of ACO measure performers, respectively