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Enzymes from the TET and JMJ family catalyse histone and DNA demethylation and they are inhibited by the accumulation succinate, the by-product of these enzymes

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Methylene blue neurological benefits include potentially improved cognitive performance and neuroprotection through mechanisms like increasing Nrf2 expression (how much of a protein, called Nuclear factor erythroid 2-related factor 2 (Nrf2), is being made or activated in the cells

doi: 10.1016/j.cell.2023.06.002 42 WangYWangH