Primary Research Areas NNMT enzymology and pharmacology the lead first-in-class selective small-molecule NNMT inhibitor used to validate the entire target class [1,2]
The resulting anemia is known as megaloblastic anemia and is the symptom for which the disease, pernicious anemia, was named (3)
Important medical disclosures Compounded medications are not FDA-approved
Thyroid conditions add complexity to any weight management approach
For CKD and ESRD patients, in spite of the increased homocysteine levels (average homocysteine level in the general population about 1015 mmol/L versus 2535 mmol/L in uremic patients), the role of homocysteine as a cardiovascular and mortality risk factor is still uncertain and many retrospective and interventional studies resulted in conflicting evidences [8,9,10,11,12]