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~5% of APAP is metabolized via oxidation by the hepatic cytochrome P450 (mainly CYP2E1) into a toxic, highly reactive intermediate metabolite N-acetyl-p-benzoquinoneimine (NAPQI) *

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This toolkit offers strategies to health care providers, communities, and local governments for developing practices and policies to help prevent opioid-related overdoses and deaths

Notch signalling drives synovial fibroblast identity and arthritis pathology

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