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Specifically, the methylation site cq21325723 (chr6:32,402,555) mediates the interaction between the SNP rs6933349 (chr6:31,002,013) and smoking, contributing to the risk of developing anti-citrulline peptide antibody (ACPA)-positive RA [39]

This copper-binding capacity enables GHK-Cu to participate in redox reactions, influence gene expression patterns, and regulate enzymatic activities critical to tissue homeostasis

Approximately 86% of patients with T2DM are overweight or obese, and obesity is considered the greatest risk factor for T2DM (Daousi et al., 2006

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