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[PMID: 26906725]

Depression in Parkinsons disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

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Yet, challenges persist in balancing specificity and off-target effects, as evidenced by hepatic sequestration of folate-conjugated nanoparticles due to nonspecific uptake by Kupffer cells, sinusoidal endothelial cells, and hepatocytes, which remains a major hurdle for systemic delivery [154]