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Beyond GLP-1/GIP dual agonism, triple-hormone receptor agonists such as retatrutide further expand this framework by engaging GIP, GLP-1, and glucagon receptors within a single molecule (109)

Several in vitro differentiation studies have established the necessity for the KDM6 H3K27me2/3 demethylases, KDM6A/UTX and KDM6B/JMJD3, in overcoming the repressive chromatin state and initiate normal transcription

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