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But the human route-comparison study does not exist, so this should not be framed as proven superiority

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This is a precaution to protect both you and the blood supply, not a direct restriction related to the medication itself

A systematic review published in PubMed found that IV glutathione is contraindicated for elective skin-lightening applications due to insufficient efficacy data and an increased risk of adverse events, while noting that glutathiones antioxidant properties offer a more plausible clinical rationale for melasma treatment