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Overall, these findings collectively demonstrate that the molecular ruthenium catalyst Ru(II)-OH and the nanoparticle formulation NP2 are therapeutically active in a 21% O 2 atmosphere, but these lose their therapeutic efficiency in a 1% O 2 atmosphere

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Most of the analyzed studies revealed that caffeine led to a beneficial effect, mitigating anxiety and depressive-like behaviors and possible cognitive impairments induced by stress

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These inconsistencies may reflect the differences in study methodologies and the need for more rigorous clinical trials with standardized endpoints and larger sample sizes