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The compound was first described in the 1990s by Predrag Sikiric and colleagues at the University of Zagreb, Croatia

Hence, even now, and despite the knowledge that APAP can cause hepatotoxicity in overdose, and the extensive research that has been conducted on its pharmacokinetics and mechanisms of toxicity over the years, there is still no quantitative model for predicting de novo the dose level at which hepatotoxicity will occur in humans and how this will vary with metabolic activity.70 Ultimately the decision to progress the development of APAP would then come down to potential risk versus benefit

If the solution needs to be mixed, gently swirl the vial rather than shaking it

Appropriate patients do not include those whose OSA develops for reasons unrelated to obesity, for example, due to anatomical issues

Guz Y, Montminy MR, Stein R, et al