The interactions between kisspeptin-10 and its receptor, G protein-coupled receptor 54 (GPR54), will be explored using binding assays, potentially unraveling novel signaling pathways activated by this interaction
(140) found that post-operative IF reduced oxidative stress in the hippocampus of 2VO rats, as evidenced by decreased MDA concentration and reduced mRNA and protein levels of the reactive oxygen-generating enzyme NADPH oxidase 1
Among them, oxidative stress refers to the excessive accumulation of reactive oxygen species (ROS) that leads to the imbalance of oxidants and antioxidants, oxidative stress has the ability to lead to mitochondrial dysfunction and lysosome dysfunction, and ultimately induces neurodegenerative disease (Caspersen et al., 2005
Bellen, Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification
Nitric oxide, also known as NO, is involved in cell communication