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What changes is the context around it

Up to 88% are also overweight or have obesity, which can cause other serious health issues

GIP receptor agonism attenuates GLP-1 receptor agonistinduced nausea and emesis in preclinical models

It has been shown to reduce the risk of major adverse cardiovascular events, such as heart attack and stroke, in clinical trials

Support and reassurance from the NHS NICE TA875 and NHS Englands 2025 implementation framework both highlight that confidence in self-injection grows with experience and good guidance