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However, the prevalence of macroscopic emphysema among cannabis-only smokers was relatively low (1.3%) compared with significantly higher rates observed in combined cannabis and tobacco users (18.9%) and tobacco-only smokers (16.3%) (9)

Ecotoxicology and Environmental Safety , published online July 18, 2019

A patient with severe COPD caused by decades of smoking who continues to smoke daily is still coded F17.210 the nicotine dependence itself is uncomplicated even if the downstream respiratory consequences are not