This results in a higher concentration of toxic metabolites which then whittle away at your gut lining
Often, lifestyle intervention is insufficient in treating obesity
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Gastrointestinal Burden GLP-1 receptor agonists slow gastric emptying and directly act on the GI tract which is why nausea, vomiting, constipation, and diarrhoea are among the most commonly reported side effects, especially during dose escalation
The combined impact of GLP-1 and GIP receptor agonism seems to support insulin secretion more effectively than either hormone alone