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Additionally, ongoing research and development efforts are needed to overcome current limitations and improve the overall safety and tolerability of GLP-1 medications.

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This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population ( The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with ( However, the relationship between BMI and response to biologic therapies is not uniformly consistent across studies