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Individuals who may need to avoid or use retatrutide with caution include: Those with severe gastroparesis or other severe gastrointestinal conditions that could be worsened by delayed gastric emptying this is a recognised caution for the class in UK SmPCs People with a history of pancreatitis , given the unconfirmed but precautionary signal associated with GLP-1-based therapies Those with a history of gallbladder disease or gallstones , given the class-associated risk of cholelithiasis and cholecystitis Those who are pregnant or breastfeeding , as safety data in these populations is entirely absent

What the Numbers Really Mean Saying that about 19 million American women are currently using GLP-1 medications does not mean all women are taking them casually or without medical need