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Combining bupropion with naltrexone (brand name Contrave ) roughly doubles average weight loss compared with bupropion alone (eClinicalMedicine 2024)
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Despite the compatibility of MT-II with a nasal spray format and the advantages of nasal delivery of peptides, there are some important factors to consider to ensure consistent dosing and maximal effectiveness: The area within the nasal membrane responsible for absorption is small and can accommodate a relatively limited volume of liquid/aerosol delivered via spray
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