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"It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants and people with severe obesity on the highest dose lost on average 30% of their body weight during two years." Importantly, treatment with retatrutide not only resulted in robust weight reduction, but also in clear improvements in assessed cardiometabolic health measures

In December 2025, Eli Lilly released Phase 3 results from the TRIUMPH-4 trial that were even more striking: 28.7% average body weight loss (approximately 71 pounds) over 68 weeks

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Treatment gives maximal benefit if started within 10 h of ingestion although it may still be beneficial for up to 2430 h

Day 02: Lima City Tour Breakfast at the hotel