With insulin dose reductions, participants treated with Jardiance and Farxiga experienced similar levels of hypoglycemia as those in the placebo group
[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Salinas C.B.G., Lu T.T., Gabery S., Marstal K., Alanentalo T., Mercer A.J., Cornea A., Conradsen K., Hecksher-Sorensen J., Dahl A.B., et al
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A caveat to all of these studies demonstrating that -cell products could play an indirect role in GLP-1-mediated regulation of glucagon is that GLP-1 maintains the ability to inhibit glucagon secretion in type 1 diabetic patients who have little to no endogenous insulin (34, 117) demonstrating that GLP-1 inhibition of glucagon secretion does not fully depend on -cell products