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Together with the pharmacodynamic data, this PK knowledge may help in selecting dosing regimens needed to achieve target exposures that maximize efficacy and minimize toxicity, advancing the translation of 7,8-DHF therapy from preclinical to clinical studies

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Based on the Gilliam Autism Rating Scale 2 (GARS-2) and the Childrens Sleep Habits Questionnaires (CSHQ), L-carnosine supplementation showed no effect on autism severity and on baseline CSHQ scales

Vitamin B12 is key for nerve function