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Other clear candidates include patients with BMI 35+ who have tried and failed multiple structured weight loss approaches, patients with obesity plus severe sleep apnea, and patients with a metabolic syndrome phenotype where reducing insulin resistance matters

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A Cox proportional hazards model was used to test for non-inferiority against the pre-specified risk margin of 1.3 for the hazard ratio (HR) of the composite of CV death, myocardial infarction (MI), or ischemic stroke (MACE) and if non-inferiority was demonstrated, to test for superiority on the two primary endpoints: 1) the composite of hospitalization for heart failure or CV death, and 2) MACE