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The effects of incretin-based therapies on metabolism and immune system are discussed and the interrelation and common features of metabolic and immune-mediated disorders are highlighted

Healthy fats may contribute to meal-stimulated GLP-1 responses, though evidence for specific fat types (like omega-3 fatty acids and monounsaturated fats) having direct GLP-1 effects is mixed and modest

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Going too long between doses could lead to a return of cravings, elevated glucose, or loss of therapeutic benefit

It was a quiet admission that the original model community-led, effort-driven, belief-based no longer makes sense in a world where weight loss can be outsourced to chemistry