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ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

HDL-C, high-density lipoprotein cholesterol

Glomerular proteinuria induces heme oxygenase-1 gene expression within renal epithelial cells

O.et al (2016)

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