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doi: 10.1152/ajprenal.00082.2009 4 CastellanaM.CignarelliA.BresciaF.PerriniS.NatalicchioA.LaviolaL.et al

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The folic-acid-conjugated enzalutamide sample displays two distinct weight-loss steps (15% to ~300 C and a further 15% to ~600 C), which is best interpreted as two different populations of organics: a low-temperature loss of loosely bound/physically adsorbed species and labile solvents/volatile residues, and a higher-temperature loss corresponding to decomposition of more strongly bound or covalently attached organic moieties (the folic-acid/drug conjugate and any drug strongly interacting with the silica surface)

Key factors influencing prognosis: 1

Under normal doses, this detoxification is efficient