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This is why the agencys PMTA review focuses not only on things that come with the product itself like ingredients, toxicology, manufacturing, packaging and labeling but also on the net public health impact of individual products at a population level, according to the FDA spokesperson

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It is usually the result of exposure to high levels of nicotine found in e-cigarette liquids, nicotine replacement products, accidental ingestion, or skin exposure, especially in children

every year roughly 347,000 deaths over the past 20 years