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Additionally, PWS individuals are more likely to have altered glucose metabolism and T2DM (173), although the exact mechanisms are still unknown

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It presents a significant diagnostic and therapeutic challenge due to its varied clinical manifestations and overlap with other liver diseases, as, for instance, primary biliary cholangitis or primary sclerosing cholangitis

When activated, these receptors slow gastric emptyingthe rate at which food leaves your stomach and enters your small intestine

82,89 Notably, the PINP/CTX and CTX/TRAcP5b ratios remain near baseline at six months, suggesting a relative balance between bone formation and resorption during this period