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Figure 6 Trichothecenes are small molecular inhibitors of protein synthesis and trigger ribotoxic stress by binding to the peptidyl transferase site of the large 60S subunit of eukaryotic ribosomes (Garreau De Loubresse et al., 2014)

doi:10.1155/2012/190930, PMID: 22934169 Kang PT, Zhang L, Chen CL, Chen J, Green KB, Chen YR (2012) Protein thiyl radical mediates S -glutathionylation of complex I

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Note that NADP + and NADPH are not the same as NAD + and NADH

Pairs with other therapies Works synergistically with Alma TED, NAD+, red light, hormone therapy, and skin-based cosmetic regimens