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This approach was taken given that PYY(336) is readily truncated or modified at the N-terminal region without loss of NPY2R agonism 54,55 , and that modification of the N-terminal region of exendin-4 produces antagonists of the GLP1-R 47 , yet the C-terminal hexapeptide is not critical for GLP1-R agonism 56

A migraine is often unilateral and pulsating, and may occur with or without an aura (Rakel 2011

10.1146/annurev-pathol-020117-043617 19