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Second-line pharmacologic therapies, which have proven efficacy in helping patients to quit but do not have an FDA indication for smoking cessation and have undesirable side effects compared to first-line agents, include clonidine (Catapres) and nortriptyline (Pamelor;Aventyl), both available by oral administration

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64 Four studies recruited both African American and Hispanic participants, with three studies reporting that depression and anxiety were associated with subsequent smoking trajectories, 43,131,156 while one study reported that smoking heaviness was associated with the onset of anxiety