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Akt is activated as a result of insulin or insulin growth factor signaling and plays a vital role in GLUT4 translocation 20

Recent studies have found that GPX4 expression in the kidneys of patients with IgA nephropathy is significantly lower than in healthy controls

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For getting more insight, the identification of factors that are capable of regulating SLC25A39 levels or mitochondrial GSH import that influence the activity and stability of proteins containing ISCs would be necessary