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In another study of 108 healthy subjects, they found that supplementing with lysine and arginine significantly reduced overall anxiety in both men and women, as well as decreasing biological anxiety markers such as salivary cortisol (male subjects only)

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doi: 10.2174/1573399812666151223093841 230 BornerTShaulsonEDTinsleyICSteinLMHornCCHayesMRet al

However, this modest difference did not reach statistical significance, and many discontinuations stemmed from reasons other than intolerable side effects

doi: 10.1177/1932296815583059