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Patients without significant cardiovascular disease who prioritize efficacy over regulatory approval status fit the Retatrutide profile well

In 2025 the FDA expanded Wegovy's indication to include adults with MASH and moderate to advanced liver fibrosis, on the strength of the ESSENCE Phase 3 trial (FDA Drugs)

Journal of Nutrition , 1996, 126:1290S-1294S

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Applying cool compresses, rotating sites, and confirming needle sterility typically resolve these responses without medication adjustment