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Unfortunately, the science is lacking on whether this approach has merit

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Metformin is an FDA-approved medication with extensive clinical outcome and safety data, while berberine is a dietary supplement with variable formulations, lower bioavailability, and less consistent research quality. Berberine may help shift the body toward better glucose and lipid metabolism, but it is not a magic weight-loss supplement and not a substitute for medical treatment and/or intervention, Katz advises

While effective for its intended purposes, some patients experience side effects, including hair loss

This expands demand beyond active users by roughly 50% in the US