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These may include issues related to intestinal permeability, irritation, or imbalance within the gut environment

Gut microbiome-produced bile acids influence glucose and lipid metabolism, energy balance, and inflammation via FXR and TGR5 receptor signaling, thus, alterations in bile acid profiles may disrupt these pathways and contribute to metabolic disease [219]

NA performed the biochemical measurements and statistical analysis and was a major contributor in writing the manuscript

Like many herbal supplements, there isnt a standard recommendation for how much milk thistle to take

10.1016/S1474-4422(21)00414-2 152 GrandeI.BerkM.BirmaherB.VietaE