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In a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity by modulating enteric neuronal function through GLP-1 receptors in submucosal and myenteric ganglion neurons [52]

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By controlling for BMI, diabetes, and other health factors, the study strengthens the link between GLP-1 exposure and enhanced sperm count, suggesting a potential therapeutic role for GLP-1s in male infertility management