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Studies have shown that allopurinol protects against diseases where oxidative stress plays a role in their pathogenesis (206)

This study not only elucidates the mechanisms of PARP1-mediated PXR E194 ribosylation in AILI but also identifies Sch B as the first specific inhibitor of this pathway, providing a theoretical basis for precision detoxification strategies targeting posttranslational modifications

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Studies were excluded if they met any of the following conditions: (1) Non-research outputssuch as conference abstracts, narrative or systematic reviews, commentaries, or editorialsthat lacked original empirical findings

Additionally, depending on the type of cell, different cell lines responded differently to the treatment with oil