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According to the randomization procedure, Group 1 was assigned to the novel methylcobalamin nasal spray (NASO B12) and Group 2 was assigned to methylcobalamin oral tablet for the treatment of vitamin B12 deficiency during the study period of 15 days [Figure 1]

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Secondary endpoints included the proportion of participants achieving 5% and 10% body weight reduction, absolute weight change in kg, change in waist circumference, lipid parameters including total cholesterol, HDL, LDL, VLDL, triglycerides, and glycaemic variables such as HbA1c, fasting glucose, insulin, HOMA-IR, and -cell function

In the subsequent phase of the study, participants were assigned to receive various interventions, namely vitamin E ( n = 30), vitamin C ( n = 30), and supragingival scaling with vitamin C ( n = 29)

Cora is roughly 60% less expensive at that comparison point with the added distinction that Ros product is FDA-approved and Coras compounded semaglutide is not