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These investigations are conducted strictly within controlled laboratory environments

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The participants supplemented daily with 1,600 IUs (40 mcg) or 3,200 IUs (80 mcg) vitamin D or placebo for five years (Virtanen 2022)

Mantovani G, Isidori AM, Moretti C, Di Dato C, Greco E, Ciolli P et al (2019) Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the SERENA study, a randomized, double-blind, placebo-controlled trial